Multimeric Biotherapeutics, Inc.

28 trimer TNFSF wheel structure
Selected Publications

Multimeric Soluble CD40 Ligand and GITR Ligand as Adjuvants for Human Immunodeficiency Virus DNA Vaccines.

G.W. Stone, S.Barzee, V.Snarsky, K.Kee, C.A. Spina, X.-F. Yu, R.S. Kornbluth. Journal of Virology 80:1762-1772, 2006.

Macaque Multimeric Soluble CD40 Ligand and GITR Ligand Constructs Are Immunostimulatory Molecules In Vitro

G.W. Stone, S. Barzee, V. Snarsky, C.A. Spina, J.D. Lifson, V.K.B. Pillai, R.A. Amara, F. Villinger, and R.S. Kornbluth. Clinical and Vaccine Immunlogy 13:1223-1230, 2006.

Immunostimulatory combinations: designing the next generation of vaccine adjuvants

R.S. Kornbluth and G.W. Stone. Journal of Leukocyte Biology 80: 1084-1102, 2006.

Nanoparticle-delivered multimeric soluble CD40L DNA combined with Toll-like receptor agonists as a treatment for melanoma

G.W. Stone, S. Barzee, V. Snarsky, C. Santucci, B. Tran, R. Langer, G.T. Zugates, D.G. Anderson, and R.S. Kornbluth. PLoS ONE 4(10): e7334. doi:10.1371/journal.pone.0007334, 2009.